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ASTM E1242-97

Historical Revision

Standard Practice for Using Octanol-Water Partition Coefficient to Estimate Median Lethal Concentrations for Fish Due to Narcosis

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1.1 This practice covers a procedure for estimating the fathead minnow (Pimephales promelas) 96-h LC50 of nonreactive (that is, covalently bonded without unsaturated residues) and nonelectrolytic (that is, require vigorous reagents to facilitate substitution, addition, replacement reactions and are non-ionic, non-dissociating in aqueous solutions) organic chemicals acting solely by narcosis, also referred to as Meyer-Overton toxicity relationship.

1.2 This procedure is accurate for organic chemicals that are toxic due to narcosis and are non-reactive and non-electrolytic. Examples of appropriate chemicals are: alcohols, ketones, ethers, simple halogenated aliphatics, aromatics, and aliphatic substituted aromatics. It is not appropriate for chemicals whose structures include a potential toxiphore (that structural component of a chemical molecule that has been identified to show mammalian toxicity, for example CN is known to be reponsible for inactivation of enzymes, NO2 for decoupling of oxidative phosphorylation, both leading to mammalian toxicity). Examples of inappropriate chemicals are: carbamates, organophosphates, phenols, beta-gamma unsaturated alcohols, electrophiles, and quaternary ammonium salts.


SDO ASTM: ASTM International
Document Number E1242
Publication Date Feb. 10, 1997
Language en - English
Page Count 2
Revision Level 97
Supercedes
Committee E47.01
Publish Date Document Id Type View
Jan. 1, 2023 E1242-23 Revision
Feb. 10, 1997 E1242-97 Revision
Oct. 1, 2014 E1242-97R14 Reaffirmation
Feb. 1, 2008 E1242-97R08 Reaffirmation
Oct. 1, 2003 E1242-97R03 Reaffirmation